WebbTNFa or TRAIL. Three signaling pathways resulting in activation of NF-jB, Erk1/2 and caspase-8 were found to be important to this novel activity of CD95. Gene chip analyses of a CD95-stimulated tumor cell line identified a number of potential survival genes and genes that are known to regulate increased motility and invasiveness WebbFasL, TRAIL, and TNF-α expressed by T cells engage with their corresponding receptor in cancer cells to initiate extrinsic apoptosis. On engagement, death receptor complexes …
To die or not to die - the quest of the TRAIL receptors
Webb摘要 目的探讨乙型肝炎病毒(hepatitis B virus,HBV)X基因(HBX)促肿瘤坏死因子相关凋亡诱导配体(TNF relatedapoptosis inducing ligand,TRAIL)蛋白诱导人肝癌细胞Huh7凋亡的机制。 方法应用脂质体转染法将pcDNA3.1-HBX、pcDNA3.1分别转染Huh7细胞,建立稳定表达HBX的细胞模型Huh7-HBX和空载体对照细胞模型Huh7-3.1;运用TRAIL蛋白分别 ... WebbFIELD OF THE INVENTION. The present invention relates to the conjugation of a cytotoxic agent to a cell-binding molecule with branch linkers for having better pharmacokinetics in logical versus physical architecture
Fas and TRAIL ‘death receptors’ as initiators of …
WebbHuman osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Many of the proinflammatory cytokines and growth factors implicated in inflammatory processes have also been demonstrated to impact osteoclast … WebbMedicinal mushrooms have important heath benefits and exhibit a broadly spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, ... Webbligands TNF, Fas ligand (FasL), and TNF-related apoptosis-inducing ligand (TRAIL). FasL binds to Fas, and in the absence of caspase 8 [39], this leads to the recruitment of FADD, RIP1 [36, 40], and RIP3 [34, 41], resulting in necroptosis. TRAIL binding to TRAIL-Rs can also result in RIP1/RIP3 necrosome formation [38]. Thus, while much remains to be logical view in dbms