Shumiya cataract rat

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August undefined, 2024

WebJul 21, 2024 · We previously designed ophthalmic nanosuspensions of LAN (LAN-ONSs) and reported that repeated instillation of LAN-ONSs attenuated the slight collapse of the lens structure in Shumiya cataract rats (SCR), although the serious structural collapses were not reversed with the instillation of LAN-ONSs, and repeated instillation could not reverse or ... WebWe discovered that the cataract development in the Shumiya cataract rat (SCR) can be prevented by the administration of deep-sea drinking water (DDW). A standard diet based …

Delay of cataract development in the Shumiya cataract rat by …

WebWe previously found that the increases in Ca 2+ content in the lenses of three hereditary cataract model rats, UPL rat (UPLR), Shumiya cataract rat (SCR) and Ihara cataract rat (ICR), are inhibited by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase, and that the mechanisms of Ca 2+ enhancement in these rat models differ. In this study, we … WebThe Shumiya cataract rat (SCR) and normal control rat strains of NC1 and NC2 were established. Mean cataract appearance in adult SCR rats was 66.7%, and embryo death … nothing as it seems pearl jam

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WebOct 25, 2024 · By positional cloning and genotyping in Shumiya cataract rats, Mori et al. (2006) identified hypomorphic mutations in the Lss gene and the Fdft1 gene, as well as a null mutation in Lss.Cataract onset was associated with the specific combination of Lss and Fdft1 mutant alleles that decreased cholesterol levels in cataractous lenses to about 57% … WebJul 10, 2003 · Methods Selenite cataract was induced in Sprague–Dawley rats by five subcutaneous injections of sodium ... activity in selenite nuclear cataract 20 and Shumiya cataract 21 in rat. ... WebSpecifically, hypomorphic LSS and farnesyl diphosphate farnesyl transferase 1 (FDFT1) mutations lower cholesterol and induce cataracts in the Shumiya cataract rat . More recently, Zhao et al. [47] identified two novel LSS mutations, G588S and W581R, from those with congenital cataracts, and treatment with lanosterol eye drops was shown to … nothing at all by heart

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WebLens reconstruction after mature cataract in SCR rat. @article{Okano1999LensRA, title={Lens reconstruction after mature cataract in SCR rat.}, author={Takuya Okano and Shigekazu Uga and S. Ishikawa and Akiko Hara and Seigou Shumiya}, journal={Japanese journal of ophthalmology}, year={1999}, volume={43 5}, pages={ 363-7 } } WebJun 1, 2006 · Search life-sciences literature (Over 39 million articles, preprints and more) how to set up bit botWebNov 28, 1997 · The Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears spontaneously in the nuclear and perinuclear portions at 11–12 weeks of … how to set up bioactive vivarium

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Shumiya cataract rat

Peptidases Play an Important Role in Cataractogenesis: An ...

WebApr 1, 2007 · Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. Mori M, Li G, Abe I, Nakayama J, Guo Z, Sawashita … WebOct 1, 2001 · Aminoguanidine-treatment results in the inhibition of lens opacification and calpain-mediated proteolysis in Shumiya cataract rats (SCR). Inomata M, Hayashi M, Shumiya S, Kawashima S, Ito Y. J Biochem, 128(5):771-776, 01 Nov 2000 Cited by: 23 articles PMID: 11056389

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WebJul 4, 2024 · The Shumiya cataract rat (SCR) is a hereditary cataractous rat strain, which is classed as two models (non-cataract type, SCR-N, and cataractous type, SCR-C) . SCR-N (ctr1 × ctr1, Ctr2 × Ctr2), without the mutations causing premature cataracts, maintains a transparent lens, although slight lens structure collapse was observed at 8–12 weeks of … WebThe Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears spontaneously in the nuclear and perinuclear portions at 11-12 weeks of age.

WebPurpose: To conduct a long-term observation study of SCR rats that had developed a mature cataract at 11 weeks of age at 3-month intervals until the rats were 12 months old. Methods: Lenses of 15 rats were examined with both light and electron microscopes.. Results: At 12 weeks, opacity was observed in the perinuclear zone and the cortical intermediate layer. WebSix-week-old Shumiya cataract rats were used to perform experiments. The right eye of each rat was injected with TAT-HA-Prdx6 WT-NPs or TAT-HA-Prdx6 K122/142R-NPs, whereas the left eyes were administered with TAT-HA-Prdx6 Inactive-mutant-NPs. The subconjuctival injection was made using micro-syringes fitted with 30-gauge needles.

WebNov 2, 2024 · The Shumiya cataract rat (SCR) is a model for hereditary cataract. Two-thirds of these rats develop lens opacity within 10-11 weeks. Onset of cataract is attributed to … WebαB-crystallin decreased with age in lens ﬁbres of cataract rats. Calpains (µ- and m-), 20S proteasome, dipeptidyl peptidases II and III and soluble alanyl aminopeptidase are …

WebMar 29, 2005 · Cataract onset is associated with the specific combination of Lss and Fdft1 mutant alleles that decrease cholesterol levels in cataractous lenses to about 57% of normal. Cholesterol insufficiency may cause the deficient proliferation of lens epithelial cells in Shumiya cataract rats, resulting in the loss of homeostatic epithelial cell control of the …

WebJun 23, 2024 · The Shumiya cataract rat (SCR) is a model for hereditary cataract. Two-thirds of these rats develop lens opacity within 10-11 weeks. Onset of cataract is attributed to the synergetic effect of lanosterol synthase (Lss) and farnesyl-diphosphate farnesyltransferase 1 … how to set up bios on hp laptopWebAug 20, 2024 · The lens of cataract rats had α-A crystallin expression levels increased by 35% when compared to the control (Fig. 2E). ... Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. J. Clin. Invest., 116 (2006), pp. 395-404. CrossRef View Record in Scopus Google Scholar how to set up bird buddyWebThe Shumiya cataract rat (SCR) is a hereditary cataractous strain. It is thought that the continuous occurrence of poorly differentiated epithelial cells at the bow area of the lens … nothing at all gifWebDelay of cataract development in the Shumiya cataract rat by water containing enhanced concentrations of magnesium and calcium Curr Eye Res. 2007 May;32(5):439-45. doi: … nothing at all air supplyWebCataract is a phenomenon in which the eye becomes opaque resulting in severe visual impairment, and senile cataract is the most common cause of blindness in the world. We … how to set up birthday reminders on iphoneWebThe Shumiya cataract rat (SCR) is a hereditary cataractous strain. It is thought that the continuous occur-rence of poorly differentiated epithelial cells at the bow area of the lens forms the pathophysiological basis for cataract formation in SCRs. In this study, we attempted to identify the genes associated with cataract how to set up bitbucketWebOct 1, 2001 · Aminoguanidine-treatment results in the inhibition of lens opacification and calpain-mediated proteolysis in Shumiya cataract rats (SCR). Inomata M, Hayashi M, … how to set up bios