Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. Hsp90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. It was originally found by its herbicidal … Zobacz więcej • Antibiotic Tan 420F • Herbimycin A Zobacz więcej Herbimycin induces the degradation of proteins that are need to be mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. … Zobacz więcej • Herbimycin A from Center for Pharmaceutical Research and Innovation Zobacz więcej • Geldanamycin • Satoshi Ōmura Zobacz więcej WitrynaNeuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A. Cancer Res. 48:6530-6534(1988) PubMed=2535691 Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A. Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. Cancer Res. 49:219 …
Ornithine Decarboxylase- and ras -Induced Cell Transformations ...
Witryna摘要： 探讨慢性髓细胞白血病细胞抗凋亡机制和诱导细胞凋亡的有效方法.方法:采用K562细胞培养,观察酪氨酸激酶抑制剂HerbimycinA联合化疗药物对细胞凋主恨的影响,探讨HMA对CML细胞的作用.结论HMA通过抑制CML细胞内酪氨酸激酶活性促进细胞凋亡而增加对化疗药物的敏感性,表明酪氨酸激酶抑制剂作为 ... WitrynaExperimental evidences suggest an important role for Fas receptor activation in a wide range of myocardial pathologies, which are associated with a variety of arrhythmias and mechanical dysfunction. Our recent studies have shown that Fas-mediated arrhythmias and mechanical disturbances of ventricular myocytes can be accounted for by … ron wiltshire occupational therapist
Total Synthesis of Herbimycin A Organic Letters
WitrynaHERBIMYCIN A Sigma Prod. No. H6649 GENERAL NOTES: HA is a benzoquinoid ansamycin antibiotic isolated from Streptomyces hygroscopicus and exerting … WitrynaIt has been shown that expression of heat shock proteins (HSPs) can interfere with the effectiveness of therapeutic cytotoxic drugs. In this study, we investigated the regulation of expression of HSPs in human epidermoid A-431 cells. Two known protein tyrosine kinase inhibitors were studied. Treatment of cells with herbimycin A increased … WitrynaHerbimycin B C28H38N2O8 CID 10007186 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... ron wimberly