Chimeric orthopoxvirus

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August undefined, 2024

WebBackground: CF33-hNIS-anti-PD-L1 is a novel chimeric orthopoxvirus shown to have anti-cancer activity in triple negative breast cancer (TNBC) xenografts. For clinical tracking of the oncolytic ... WebCF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust preclinical activity ...

A Novel Oncolytic Chimeric Orthopoxvirus Encoding …

WebFeb 4, 2024 · CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). The in vitro cytotoxic ability of this virus against five PDAC cell lines was tested at various doses (multiplicity of infection (MOI) = 0.01, 0.1, 1, 10). Production and … Weborthopoxvirus vectors, genes and products thereof专利检索，orthopoxvirus vectors, genes and products thereof属于···痘苗病毒或天花病毒专利检索，找专利汇即可免费查询专利，···痘苗病毒或天花病毒专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 jerry white author

Novel Chimeric Immuno-Oncolytic Virus CF33-hNIS-antiPDL1 for …

WebFor these studies, we used an oncolytic chimeric orthopoxvirus, de-signed to infect a large spectrum of tumors (13–17), carrying CD19t under the control of the vaccinia synthetic early promoter (P SE; Fig. 1A). This construction enables rapid expression of CD19t and appearance of the protein at the cell surface before oncolytic viral- WebOrthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae.Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. … WebNational Center for Biotechnology Information jerry white attorney at law logan wv

Endogenous Akt Activity Promotes Virus Entry and …

A Study of CF33-hNIS (VAXINIA), an Oncolytic Virus, as …

WebJun 6, 2024 · CF33-hNIS Infects, Replicates in, and Kills Colon Cancer Cells. Chimerization and high-throughput analysis yielded a successful chimeric orthopoxvirus candidate that resulted in superior cell killing and viral replication when compared with parental strains, as previously reported.14, 15, 16 Insertion of hNIS at the tk locus (Figure 1 A) resulted in … jerry whitehead paintingsWebJun 29, 2024 · Chimeric Orthopoxvirus CF33 Effectively Kills TNBC In Vitro CF33 demonstrates both time- and dose-dependent cytotoxicity against four different TNBC … packaging for cakes and cupcakes

"WebOct 9, 2024 · The conditionally replication-competent chimeric orthopoxvirus (CF17) successfully exhibited the ability to suppress tumor growth and increase survival in preclinical peritoneal ovarian metastases … " - Chimeric orthopoxvirus

Chimeric orthopoxvirus

WebStudy design: CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody … WebJun 17, 2024 · A novel oncolytic chimeric orthopoxvirus encoding luciferase enables real-time view of colorectal cancer cell infection. Mol Ther Oncolytics. 2024;9:13–21. PubMed PubMed Central Google Scholar

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WebApr 28, 2024 · Chimeric Orthopoxvirus CF33 Effectively Kills TNBC In Vitro CF33 demonstrates both time- and dose-dependent cytotoxicity against four different TNBC cell lines. In the BT549, Hs578T, and MDA … WebCF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). The in vitro cytotoxic ability of this virus against 5 PDAC cell lines was tested at various doses (multiplicity of infection [MOI] = 0.01, 0.1, 1, 10).

WebJul 6, 2024 · One such OV is CF33, a chimeric poxvirus created by chimerization of nine species of orthopoxvirus, including multiple strains of vaccinia virus selected for enhanced anti-tumor activity. 23 O’Leary M.P. WebApr 1, 2024 · Study Design. CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). The in vitro cytotoxic ability of this virus against 5 PDAC cell lines was tested at various doses (multiplicity of infection [MOI] = 0.01, 0.1, 1, 10).

WebSep 25, 2024 · Anthony K. Park et.al utilized an oncolytic chimeric orthopoxvirus carrying a CD19t-encoding gene to infect solid tumor cells including those of pancreatic cancer, prostate cancer, and breast cancer. They demonstrated that OVs can effectively deliver the CD19-CAR target to solid tumors and upregulate the expression of CD19t on the surface … WebNov 4, 2024 · Description: This licence authorises Medpace Australia Pty Ltd to conduct a clinical trial of a genetically modified (GM) chimeric orthopoxvirus as a cancer treatment in Australia. The genetically modified organism (GMO) is genetically similar to the vaccinia virus used as a vaccine during the global smallpox eradication campaign.

WebApr 12, 2024 · A novel chimeric orthopoxvirus (CF33) was constructed. The thymidine kinase locus was replaced with firefly luciferase (Fluc) to yield a recombinant virus—CF33-Fluc. In vitro cytotoxicity and viral replication …

WebJul 6, 2024 · Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model Mol Ther Oncolytics. 2024 Jul 6;18:326-334. doi: 10.1016/j ... that this NSC line can improve the delivery of a thymidine kinase gene-deficient conditionally replication-competent orthopoxvirus, CF33, in a … packaging for cake slicesWebCF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). … packaging for dried herbsWebOrthopoxvirus (OPV) is a genus of closely related, large DNA viruses that encode about 200 genes. OPV includes some pathogenic species with strict host restriction such as … jerry whiteheadWebSep 9, 2024 · One such OV is CF33, a chimeric poxvirus created by chimerization of nine species of orthopoxvirus, including multiple strains of vaccinia virus selected for enhanced anti-tumor activity.23, 24, 25 CF33 has a mutation in the J2R (thymidine kinase [TK]) gene, and hence it depends on the cellular pool of thymidine triphosphate. jerry white wswsWebCF33-hNIS, a novel chimeric orthopoxvirus, will be administered as a monotherapy or in combination with pembrolizumab to assess the safety and efficacy of the treatment … jerry white shoshone county assessorWebJun 29, 2024 · A Novel Oncolytic Chimeric Orthopoxvirus Encoding Luciferase Enables Real-Time View of Colorectal Cancer Cell Infection Michael P.O’Leary14 Susanne … packaging for clothing lineWebFor these studies, we used an oncolytic chimeric orthopoxvirus, designed to infect a large spectrum of tumors (13) (14)(15)(16)(17), carrying CD19t under the control of the vaccinia synthetic ... jerry whitehead facilities